• DISEASE MOUSE MODELS

    Model animals, as an important tool for human disease research, aid in the investigation of disease mechanisms and the development of therapies. Mouse models, being the most extensively used model animals, are employed in a variety of areas, such as fundamental scientific research, drug discovery, preclinical evaluation, and clinical technology development. Mice have a close relationship with humans, advanced genetic manipulation, fast reproduction, and a clear genetic background. Gene editing technology can provide suitable disease models for study based on disease-related genes. GemPharmatech has produced numerous disease models using gene editing technologies, such as spontaneous tumor models, obesity models, diabetes models, Alzheimer's disease models, Parkinson's disease models, and so on. Through phenotypic analysis, GemPharmatech has also confirmed the incidence and development of numerous model-related phenotypes, providing solid support for the research of various diseases.

    Introducing GemPharmatech's Latest Strains: Unveiling the Future of Innovation


    Strain ID

    Strain Name

    Application

    T055223


    B6-Tg(hSOD1 G93A,hSOD1) 图片1.png

    Genetic humanization, ALS disease

    T058996

    FAD4T-hTREM2 图片1.png

    Genetic humanization, Alzheimer's disease

    T054322

    B6-hSNCA E46K A53T

    Genetic humanization, Parkinson's disease

    T056757

    B6-hCD36

    Genetic humanization, neuroinflammation

    T056002

    B6-Dmd Del45

    Duchenne muscular dystrophy, 45 exon deletion

    T055631

    B6-hDLL4

    Genetic humanization, oncology

    T056429

    B6-hCD34

    		Genetic humanization, oncology

    T058753

    B6-hCEACAM5-Tg

    		Genetic humanization, oncology

    T053316

    B6-hIL18R1/hIL18RAP

    		Genetic humanization, oncology

    T037007

    B6-hCD47/hSIRPA 图片1.png

    		Genetic humanization, oncology

    T056010

    BALB/c-hCD44

    		Genetic humanization, oncology

    T054198

    BALB/c-hGPC3

    		Genetic humanization, oncology

    T054490

    BALB/c-hSEMA4D

    		Genetic humanization, oncology

    T054543

    BALB/c-hHSA

    		Genetic humanization, oncology

    T056432

    BALB/c-hTROP2 图片1.png

    		Genetic humanization, oncology

    T056011

    BALB/c-hCD44v6

    		Genetic humanization, oncology

    T055714

    BALB/c-hCS1

    		Genetic humanization, oncology

    T056083

    BALB/c-hLRRC15

    		Genetic humanization, oncology

    T056430

    BALB/c-hNECTIN-4

    		Genetic humanization, oncology

    T058266

    BALB/c-hTIGIT/hPVRIG

    		Genetic humanization, oncology

    T054842

    BALB/c-hPD1/hPDL1/hTIGIT/hCD9 图片1.png

    		Genetic humanization, oncology

    T058749

    BALB/c-hPD1/hPDL1/hCD73/hCD39 图片1.png

    		Genetic humanization, oncology

    T009819


    BALB/c-hHER2 图片1.png


    		Genetic humanization, oncology

    T009813

    NCG-hHER2

    		Genetic humanization, oncology

    T054081

    NOD-Scid-hNKp30

    		Genetic humanization, oncology

    T056195

    B6-hIGHA1

    Genetic humanization, autoimmune disease


    T054583

    BALB/c-hIL1RL1

    Genetic humanization, autoimmune disease

    T054645

    BALB/c-hKLRB1

    Genetic humanization, autoimmune disease

    T003277

    BALB/c-hIL17A 图片1.png

    Genetic humanization, autoimmune disease

    T053555

    BALB/c-hIL1β

    Genetic humanization, autoimmune disease

    T054186

    BALB/c-hTLR8

    Genetic humanization, autoimmune disease

    T055268

    BALB/c-hFcgRs/hCD47/hSIRPA 图片1.png

    Genetic humanization, Fc end modification for antibody drugs, ADCC effect

    T058940

    BALB/c-hCD3EDG/hCD22

    Genetic humanization, CD3 bispecific antibody related

    T057420

    BALB/c-hCD73/hCD3EDG 

    Genetic humanization, CD3 bispecific antibody related

    T058817

    BALB/c-hGPRC5D/hCD3EDG 图片1.png

    Genetic humanization, CD3 bispecific antibody related

    T059045

    BALB/c-hCD3EDG/hBCMA 图片1.png

    Genetic humanization, CD3 bispecific antibody related

    T058351

    B6-Rosa26-hAGT 图片1.png

    Genetic humanization, hypertension

    T058352

    B6-H11-hREN

    Genetic humanization, hypertension

    T054639

    B6-hCD200R1

    Genetic humanization, atherosclerosis research

    T058217

    B6-hAPOB-Tg

    Genetic humanization, hypercholesteremia and atherogenesis

    T058211

    B6-hAPOE-DGAT2-LE1 图片1.png

    Genetic humanization, NASH

    T051403

    B6-Myh6-R404Q 图片1.png

    Hypertrophic cardiomyopathy

    T027708

    B6-Mybpc3-KO

    hypertrophic cardiomyopathy or dilated cardiomyopathy

    T007085

    B6-Kras-G12D/wt; Lyz2-iCre

    Spontaneous lung cancer

    T053603

    kras-G12C 图片1.png

    Kras-related spontaneous tumors

    T057165

    KPS 图片1.png

    Spontaneous lung cancer

    T057162

    KS

    Spontaneous lung cancer